The head administrator for the HQOC is Karl Coleman. Adam Ackerman leads financial management.

The HQOC is directed by Prof. John Doyle. A Scientific Board, chaired by Prof. Mikhail Lukin and whose membership is Profs. Roy Glauber, Evelyn Hu, Markus Greiner, Eugene Demler, Hongkun Park and Marko Loncar, sets scientific directions for the Center. Both the director and the board report to the Dean of the FAS. An advisory committee composed of distinguished scientists from outside of Harvard will, on a yearly basis, consider the past year’s activities of the Center and report to the Dean, with a copy to the Director, their judgement of the scientific and educational effectiveness of the Center.